The Effect of Zizyphus spina-christi Extracts on hyperglycemia induced by hyperlipidemic diet in Albino rats

Abstract

The study was carried out to evaluate the protective effects of Ziziphus Spina Christi (ZSC) leaves, fruits and seed extracts to ameliorate the adverse effects of hyperglycemia induced in Albino rats.

Ziziphus Spina Christi seeds, fruit and leaves extracts revealed positive results for carbohydrates, phenols, saponins, alkaloids, tannins, steroids, and flavonoids. High-fat diet intake has been associated with many pathological alterations in all studied parameters; one of these pathological alterations was hyperglycemia. Treatment of hyperglycemic rats with ZSC leaves, fruits and seeds extracts reduced these pathological alterations. Hyperglycemic rats were treated with ZSC seeds, fruit and leaves ethanolic extracts separately and in combination for 7 weeks. Results showed that the extracts succeeded in reducing the elevated glucose, insulin and HbA1C levels. On the other hand, the extracts improved histological alterations induced by a hyperlipidemic diet.