Synthesis and characterization of mixed ligand complexes of Fluconazole drug and glycine with some transition metals: antifungal study

https://doi.org/10.59628/jast.v3i2.1534

Authors

  • Yasmin Jamil Department of Chemistry, Faculty of Science, Sana’a University, Sana’a, Yemen https://orcid.org/0000-0003-1585-3770
  • Majeda M. Al-Baseer Department of Chemistry, Faculty of Science, Sana’a University, Sana’a, Yemen
  • Basem Al-Akhali Department of Microbiolgy, Faculty of Science, Sana’a University, Sana’a, Yemen
  • Ahmed N. Alhakimi Department of Chemistry, Faculty of Science, Ibb University, Ibb, Yemen

Keywords:

Propagation, Intensity, Phase, Beam, Distribution of Beam

Abstract

Mixed ligand complexes of fluconazole (FCZ), like the main ligand and glycine (Gly) as the secondary ligand, were synthesized and characterized using elemental analysis, spectroscopy, infrared and electronic spectra, magnetic susceptibility, and molar conductivity. The results showed that 1:1:1 [M:L1:L2] octahedral complexes were formed, with FCZ coordinating through its C=N group and glycine coordinating through its carboxylic oxygen and amino nitrogen. Molar conductivity indicated the complexes were not electrolytic in nature. The antifungal activity of FCZ, glycine, and their metal complexes with Cu, Ni, and Cd was tested against Aspergillus niger, Peni- cillium italicum, and Candida albicans. Cadmium complex [Cd(FCZ)(Gly (H2O)2Cl].2H2O showed significantly enhanced activity with outperforming the standard antifungal agent Nystatin against A. niger and P. italicum. These findings highlight the potential of such complexes as effective antifungal agents.

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Chemical structure of fluconazole

Published

2025-04-30

How to Cite

Jamil, Y., Al-Baseer, M. M., Al-Akhali, B., & Alhakimi, A. N. (2025). Synthesis and characterization of mixed ligand complexes of Fluconazole drug and glycine with some transition metals: antifungal study. Sana’a University Journal of Applied Sciences and Technology , 3(2), 718–729. https://doi.org/10.59628/jast.v3i2.1534

Issue

Vol. 3 No. 2 (2025): Sana'a University Journal of Applied Sciences and Technology

Section

Article
Copyright & Licensing

Copyright (c) 2025 Yasmin Jamil, Majeda M. Al-Baseer, Basem Al-Akhali, Ahmed N. Alhakimi

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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