Synthesis and characterization of mixed ligand complexes of Fluconazole drug and glycine with some transition metals: antifungal study

https://doi.org/10.59628/jast.v3i2.1534

المؤلفون

  • Yasmin Jamil Department of Chemistry, Faculty of Science, UDepartment of Chemistry, Faculty of Science, Sana’a University, Sana’a, Yemenniversity of Sana’a, Sana’a, Yemen https://orcid.org/0000-0003-1585-3770
  • Majeda M. Al-Baseer Department of Chemistry, Faculty of Science, Sana’a University, Sana’a, Yemen
  • Basem Al-Akhali Department of Microbiolgy, Faculty of Science, Sana’a University, Sana’a, Yemen
  • Ahmed N. Alhakimi Department of Chemistry, Faculty of Science, Qassim University, Qassim, Buraidah, Saudi Arabia

الكلمات المفتاحية:

Propagation، Intensity، Phase، Beam، Distribution of Beam

الملخص

Mixed ligand complexes of fluconazole (FCZ), like the main ligand and glycine (Gly) as the secondary ligand, were synthesized and characterized using elemental analysis, spectroscopy, infrared and electronic spectra, magnetic susceptibility, and molar conductivity. The results showed that 1:1:1 [M:L1:L2] octahedral complexes were formed, with FCZ coordinating through its C=N group and glycine coordinating through its carboxylic oxygen and amino nitrogen. Molar conductivity indicated the complexes were not electrolytic in nature. The antifungal activity of FCZ, glycine, and their metal complexes with Cu, Ni, and Cd was tested against Aspergillus niger, Peni- cillium italicum, and Candida albicans. Cadmium complex [Cd(FCZ)(Gly (H2O)2Cl].2H2O showed significantly enhanced activity with outperforming the standard antifungal agent Nystatin against A. niger and P. italicum. These findings highlight the potential of such complexes as effective antifungal agents.

التنزيلات

بيانات التنزيل غير متوفرة بعد.
Chemical structure of fluconazole

منشور

2025-04-30

كيفية الاقتباس

Jamil, Y., Al-Baseer, M. M., Al-Akhali, B., & Alhakimi, A. N. (2025). Synthesis and characterization of mixed ligand complexes of Fluconazole drug and glycine with some transition metals: antifungal study. مجلة جامعة صنعاء للعلوم التطبيقية والتكنولوجيا, 3(2), 718–729. https://doi.org/10.59628/jast.v3i2.1534

إصدار

مجلد 3 عدد 2 (2025)

القسم

المقالات
Copyright & Licensing

الحقوق الفكرية (c) 2025 Yasmin Jamil, Majeda M. Al-Baseer, Basem Al-Akhali, Ahmed N. Alhakimi

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هذا العمل مرخص بموجب Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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