Solvent-Free One-Pot Synthesis of Butyl N-[(2-Hydroxy-1-naphthyl)(aryl)methyl]carbamate Derivatives and Their Biological Evaluation

الشريط الجانبي للمقالة

Antibacterial activity of synthesized compounds
PDF (الإنجليزية)
منشور: 2025-10-28
DOI: https://doi.org/10.59628/jast.v3i5.1954
الكلمات المفتاحية:
Carbamatoalkyl naphthol’s، Cerium ammonium nitrate، One-pot synthesis، Solvent-free condition.

محتوى المقالة الرئيسي

Sadeq H Saleh Azzam
Department of Chemistry, Faculty of Sciences, Sana’a University, Sana’a, Yemen
Sami Q.S. Abdullah
Department of Chemistry, Faculty of Sciences, Dhamar University, Dhamar, Yemen
Maher A Al Maqtari
Department of Chemistry, Faculty of Sciences, Sana’a University, Sana’a, Yemen
Mona Saad Al-Ezzi
Department of Chemistry, Faculty of Sciences, Dhamar University, Dhamar, Yemen

الملخص

We report a highly efficient method for synthesizing carbamatoalkyl naphthols via one-pot, three-component condensation involving 2-naphthol, aldehydes, and butyl carbamates. This reaction, facilitated by cerium ammonium nitrate, can be performed under solvent-free conditions at 80°C and generally occurs within a short time frame. The resulting compounds were thoroughly characterized by FT-IR, 1H NMR, 13C NMR, and mass spectrometry. Additionally, the antimicrobial properties and biocompatibility of the newly synthesized compounds were evaluated using laboratory tests. The findings indicated that these compounds exhibited significant biological activity compared to standard antibiotics, and their hemocompatibility was confirmed.

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تفاصيل المقالة

إصدار

مجلد 3 عدد 5 (2025): Sana'a University Journal of Applied Sciences and Technology

القسم

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Creative Commons License

هذا العمل مرخص بموجب Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

كيفية الاقتباس

Solvent-Free One-Pot Synthesis of Butyl N-[(2-Hydroxy-1-naphthyl)(aryl)methyl]carbamate Derivatives and Their Biological Evaluation. (2025). مجلة جامعة صنعاء للعلوم التطبيقية والتكنولوجيا, 3(5), 1043-1055. https://doi.org/10.59628/jast.v3i5.1954

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