Hematological Abnormalities in Patients with Chronic Liver Disease Attending Republican Teaching Hospital Authority in Sana’a city, Yemen
Background: Chronic liver disease (CLD) is frequently associated with hematological abnormalities, contributing significantly to patient morbidity and mortality. However, data on this topic are scarce in Yemen.
Objectives: This study aimed to evaluate the spectrum and magnitude of hematological abnormalities in patients with CLD who attended the Republican Teaching Hospital Authority in Sana’a City, Yemen.
Methods: A cross-sectional study was conducted from September 2024 to June 2025, involving 400 patients with CLD diagnosed clinically and by ultrasonography. Three milliliters of venous blood was collected for complete blood count analysis. Data were analyzed using SPSS version 26.
Results: The mean age of the participants was 41.1 ± 14.4 years, with a male predominance (68.8%). Anemia was observed in 60.5% of the patients (27.3% mild, 56.6% moderate, and 16.1% severe). Leukopenia affected 43.0% (87.8% mild, 11.6% moderate, and 0.6% severe) of the patients, whereas leukocytosis was rare (5.5%). Thrombocytopenia was highly prevalent at 65.8% (42.6% mild, 47.1% moderate, and 10.3% severe), with thrombocytosis noted in only 0.5% of patients. Chi-square analysis showed that the distributions of anemia, leukopenia, and thrombocytopenia were statistically significant (p < 0.001).
Conclusion: Hematological abnormalities, particularly anemia and thrombocytopenia, are highly prevalent among CLD patients in Sana’a, Yemen, often presenting in moderate to severe forms. Early detection and management of these complications are crucial for improving patient outcomes.
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