Solvent-Free One-Pot Synthesis of Butyl N-[(2-Hydroxy-1-naphthyl)(aryl)methyl]carbamate Derivatives and Their Biological Evaluation

Abstract

We report a highly efficient method for synthesizing carbamatoalkyl naphthols via one-pot, three-component condensation involving 2-naphthol, aldehydes, and butyl carbamates. This reaction, facilitated by cerium ammonium nitrate, can be performed under solvent-free conditions at 80°C and generally occurs within a short time frame. The resulting compounds were thoroughly characterized by FT-IR, ¹H NMR, ¹³C NMR, and mass spectrometry. Additionally, the antimicrobial properties and biocompatibility of the newly synthesized compounds were evaluated using laboratory tests. The findings indicated that these compounds exhibited significant biological activity compared to standard antibiotics, and their hemocompatibility was confirmed.