Intratympanic platelet-rich plasma injection for the treatment of sensorineural hearing loss: a prospective study Intratympanic platelet-rich plasma injection for the treatment of sensorineural hearing loss: a prospective study

Abstract

Background: This study aimed to evaluate the efficacy and safety of intratympanic PRP injection for the treatment of SNHL in Yemen and to identify predictors of successful treatment outcomes.

Methods: This prospective cohort study included 120 patients diagnosed with SNHL at the Military General Hospital in Yemen. The patients received intratympanic PRP injections and were followed up for 3 months. Pure-tone audiometry (PTA) was performed to assess hearing thresholds before and after treatment. Demographic and clinical characteristics, including etiology and duration of hearing loss, were collected. Statistical analysis was performed to evaluate the treatment outcomes and identify significant predictors.

Results: The study cohort comprised 36 women (30%) and 84 men (70%), with a mean age of 29.72 ± 11.85 years. The most common etiologies were noise-induced hearing loss (35.8%) and sudden hearing loss (30%). Posttreatment, significant improvement in PTA hearing thresholds was observed, with mean thresholds improving from 48.27 ± 17.77 dB HL to 31.56 ± 20.45 dB HL (p < 0.05). Patients with pre-treatment hearing levels of 26-45 dB showed the highest improvement rates, with 100% achieving a final hearing level of ≤ 25 dB. The etiology of SNHL was a significant predictor of better outcomes (p = 0.002), whereas age, sex, and duration of hearing loss did not significantly affect treatment outcomes. The treatment was well-tolerated, with minor adverse effects observed in a small percentage of patients.

\newline\textbf {Conclusion: } Intratympanic injections of PRP are an effective and safe treatment for improving hearing thresholds in patients with SNHL, particularly in resource-limited settings like Yemen. Early intervention and tailored treatment strategies based on etiology are crucial for optimizing the outcomes. Further studies with larger sample sizes and longer follow-up periods are required to establish the long-term efficacy and safety of PRP therapy in patients with SNHL.

Conventions: Abbreviations are usually defined at the first use in the abstract. Check whether 'PRP' should be defined here.

Consistency: Different forms of this word have been used in the text.
'posttreatment' no space [4 times]
'post-treatment' with hyphen [4 times]
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Consistency: Different forms of this word have been used in the text.
'pre-treatment' with hyphen [7 times]
'pretreatment' no space [3 times]
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Conventions: Abbreviations are usually defined at the first use in the abstract. Check whether 'SNHL' should be defined here.