12609
S. S. Abbas, N. E. Wagieh, M. Abdelkawy, and M. M. Abdelrahman, “Simultaneous determination of diloxanide furoate and metronidazole in presence of diloxanide furoate degradation products,” J. AOAC Int., vol. 94, no. 5, pp. 1427–1439, 2011, doi: 10.5740/jaoacint.10-286. [2] K. R. Danao, S. M. Hiradeve, R. S. Moon, A. V. Kasture, and P. G. Yeole, “RP-HPLC simultaneous estimation of metronidazole and diloxanide furoate in combination,” Int. J. Pharm. Life Sci., vol. 1, no. 2, pp. 82–85, 2010. [3] United States Pharmacopeia (USP 48 – NF 43), “Diloxanide Furoate,” 2025, doi: 10.31003/USPNF_M26310_03_01. [4] K. D. Tripathi, Essentials of Medical Pharmacology, 7th ed. New Delhi: Jaypee Brothers Medical Publishers, 2013, pp. 837–839. [5] M. M. Abdelrahman, N. W. Ali, S. S. Abbas, H. E. Zaazaa, and M. Abdelkawy, “Stability indicating double divisor spectrophotometric method for determination of diloxanide furoate and metronidazole in their binary mixture,” Int. J. Clin. Med. Res., vol. 1, no. 2, pp. 55–65, 2023, doi: 10.61466/ijcmr1020008. [6] M. R. El-Ghobashy and N. F. Abo-Talib, “Spectrophotometric methods for the simultaneous determination of binary mixture of metronidazole and diloxanide furoate without prior separation,” J. Adv. Res., vol. 1, no. 4, pp. 323–329, 2010, doi: 10.1016/j.jare.2010.06.001. [7] N. H. Al-Shaalan, “Determination of diloxanide furoate and metronidazole in binary mixture using first derivative of the ratio-spectra and high-performance liquid chromatography-UV methods,” Am. J. Appl. Sci., vol. 4, no. 2, pp. 66–72, 2007, doi: 10.3844/ajassp.2007.66.72. [8] S. Naveed and F. Qamar, “Simple UV spectrophotometric assay of metronidazole,” OAlib, vol. 1, no. 6, pp. 1–4, 2014, doi: 10.4236/oalib.1100615. [9] S. H. Hasan, N. S. Abdullah, and M. A. Hassan, “Spectrophotometric methods for determination of metronidazole in pharmaceutical formulations,” Zanco J. Pure Appl. Sci., vol. 30, no. 5, 2018, doi: 10.21271/ZJPAS.30.5.7. [10] M. M. Morcoss, N. S. Abdelwahab, N. W. Ali, and M. T. Elsaady, “Different chromatographic methods for simultaneous determination of diloxanide furoate, metronidazole and its toxic impurity,” J. Iran. Chem. Soc., vol. 13, no. 9, pp. 1643–1651, 2016, doi: 10.1007/s13738-016-0881-3. [11] C. F. Ferraro, P. M. Castellano, and T. S. Kaufman, “Chemometric determination of amiloride hydrochlorothiazide and timolol maleate in synthetic mixture and pharmaceutical formulation,” J. Pharm. Biomed. Anal., vol. 34, pp. 305–314, 2004. [12] F. Belal, F. Ibrahim, Z. A. Sheribah, and H. Alaa, “New spectrophotometric/chemometric assisted methods for the simultaneous determination of imatinib, gemifloxacin, nalbuphine and naproxen,” Spectrochim. Acta A Mol. Biomol. Spectrosc., vol. 198, pp. 51–60, 2018. [13] M. Khalili, M. R. Sohrabi, M. Vahid, and N. T. Ziaratgahi, “Chemometric simultaneous determination of sofosbuvir and ledipasvir in pharmaceutical dosage form,” Spectrochim. Acta A Mol. Biomol. Spectrosc., vol. 194, pp. 141–151, 2018. [14] V. D. Singh and S. J. Daharwal, “Development and validation of multivariate calibration methods for simultaneous estimation of paracetamol, enalapril maleate and hydrochlorothiazide,” Spectrochim. Acta A Mol. Biomol. Spectrosc., vol. 171, pp. 369–375, 2017. [15] K. Palur, S. C. Archakam, and B. Koganti, “Chemometric assisted UV spectrophotometric and RPHPLC methods for simultaneous determination of paracetamol, diphenhydramine, caffeine and phenylephrine in tablet dosage form,” Spectrochim. Acta A Mol. Biomol. Spectrosc., vol. 243, pp. 127, 2020. [16] M. Albayrak, F. Miloglu, D. O. Senol, and E. Polatdemir, “Design, optimization, and validation of chemometrics-assisted spectrophotometric methods for simultaneous determination of etodolac and thiocolchicoside in pharmaceuticals,” J. Anal. Sci. Technol., vol. 16, pp. 2–8, 2019. [17] S. Gummadi and P. Chandaka, “Chemometrics approach to drug analysis – an overview,” Am. J. Pharm. Tech. Res., vol. 9, pp. 1–13, 2019. [18] A. Jahangiri, K. Adakai, M. B. Jalali, A. K. Zeynali, Y. Javadzadeh, and H. Hamishehkar, “Application of multivariate calibration methods in dissolution testing and simultaneous determination of atorvastatin and ezetimibe,” J. Pharm. Sci., vol. 22, pp. 105–111, 2016. [19] H. W. Darwish, S. A. Hassan, M. Y. Salem, and B. A. El-Zeany, “Comparative study between derivative spectrophotometry and multivariate calibration for simultaneous quantitation of amlodipine, valsartan and hydrochlorothiazide,” Spectrochim. Acta A Mol. Biomol. Spectrosc., vol. 113, pp. 215–223, 2013. [20] N. H. Al-Shaalan, “Determination of phenylephrine hydrochloride and chlorpheniramine maleate in binary mixture using chemometric-assisted spectrophotometric and HPLC-UV methods,” J. Saudi Chem. Soc., vol. 14, no. 1, pp. 15–21, 2010. [21] N. S. Patel, V. P. Nandurbarkar, A. J. Patel, and S. G. Patel, “Simultaneous spectrophotometric determination of celecoxib and diacerein by absorption correction and chemometric methods,” Spectrochim. Acta A Mol. Biomol. Spectrosc., vol. 125, pp. 46–52, 2014. [22] Y. Ni, Y. Wang, and S. Kokot, “Multicomponent kinetic spectrophotometric determination of pefloxacin and norfloxacin in pharmaceutical preparations and human plasma samples with the aid of chemometrics,” Spectrochim. Acta A Mol. Biomol. Spectrosc., vol. 70, pp. 1049–1059, 2008. [23] L. Gao and S. Ren, “Simultaneous spectrophotometric determination of four metals by the kernel partial least squares method,” Chemom. Intell. Lab. Syst., vol. 45, pp. 87–93, 1999. [24] M. Almaqtari, N. Al-Odaini, F. Alarbagi, B. Alattab, and H. Al-Maydama, “Development and validation of a new spectrophotometric method for simultaneous determination of spiramycin and metronidazole using chemometrics technique,” Sana’a Univ. J. Appl. Sci. Technol., vol. 1, no. 1, 2023, doi: 10.59628/jast.v1i1.34. [25] Z. Wang, P. Wu, Y. Zhao, X. Li, and D. Kong, “Application of excitation-emission matrix fluorescence spectroscopy and chemometrics for quantitative analysis of emulsified oil concentration,” Spectrochim. Acta A Mol. Biomol. Spectrosc., vol. 328, 125423, 2025, doi: 10.1016/j.saa.2024.125423. [26] J. Ezenarro and D. Schorn-García, “How are chemometric models validated? A systematic review of linear regression models for NIRS data in food analysis,” J. Chemom., vol. 39, no. 6, 2025, doi: 10.1002/cem.70036. [27] N. G. Schumer, M. W. Ahmed, K. Rausch, V. Singh, and M. Kamruzzaman, “Chemometric-based approach for economically motivated fraud detection in organic spices via NIR spectroscopy,” J. Food Compos. Anal., vol. 142, 107538, 2025, doi: 10.1016/j.jfca.2025.107538. [28] R. Jamwal et al., “Recent trends in the use of FTIR spectroscopy integrated with chemometrics for detection of edible oil adulteration,” Vib. Spectrosc., vol. 113, 103222, 2021, doi: 10.1016/j.vibspec.2021.103222. [29] E. Deconinck, C. Duchateau, M. Balcaen, L. Gremeaux, and P. Courselle, “Chemometrics and infrared spectroscopy – a winning team for the analysis of illicit drug products,” Rev. Anal. Chem., vol. 41, no. 1, pp. 228–255, 2022, doi: 10.1515/revac-2022-0046. [30] M. Ahmed, S. N. R. Sanjana, and S. K. Shetty, “Development and validation of UV spectrophotometric methods for simultaneous estimation of itraconazole and terbinafine hydrochloride,” Human J., vol. 18, no. 3, 2020. [31] S. Yenduri, K. N. Prashant, and H. N. Varalakshmi, “Spectrophotometric approach for deconvolving overlapped spectra of antihypertensive drug mixtures using UV detection: an eco-friendly method,” BMC Chem., vol. 19, no. 1, p. 211, Jul. 2025, doi: 10.1186/s13065-025-01565-4. [32] G. G. Dumancas et al., “Chemometrics for quantitative determination of terpenes using ATR-FTIR spectroscopy: a pedagogical laboratory exercise,” J. Chem. Educ., vol. 100, no. 8, pp. 3050–3060, Aug. 2023, doi: 10.1021/acs.jchemed.3c00358. [33] P. Borman and D. Elder, “Q2(R1) validation of analytical procedures,” in ICH Quality Guidelines, Wiley, 2017, pp. 127–166, doi: 10.1002/9781118971147.ch5. [34] International Conference on Harmonization (ICH), Guideline Q2(R1): Validation of Analytical Procedures, Geneva, Switzerland, 2022. [35] United States Pharmacopeia (USP 48 – NF 43), “Metronidazole Tablets,” 2025, doi: 10.31003/USPNF_M53700_03_01.