Evaluation Of Paraoxonase-1 Activity In Yemeni Type 2 Diabetes Mellitus And Its Association With Atherogenic Risk Factors

Abstract

Objective: To evaluate the Paraoxonase-1 (PON1) activity in Yemeni patients with Type 2 DM and examine its association with the atherogenic risk factors. Methods: This was a case-control study carried out on 97 subjects: 46 healthy subjects from both genders (control) and 51 Type 2 DM patients. Biochemical parameters include PON1, fasting blood glucose (FBG), glycated hemoglobin (HbA1c), and lipid profile were analyzed. Results: Serum PON1 was significantly (p = 0.001) lower in Type 2 DM patients by 10.1% with respect to the healthy control subjects. Moreover, FBG, HbA1c and total cholesterol were significantly higher in Type 2 DM patients as compared to the healthy controls. Serum PON1 activity was positively correlated with high-density lipoprotein cholesterol – HDL-c (r = 0.383, p = 0.006) and inversely correlated with HbA1c (r = - 0.341, p = 0.014). Conclusion: Paraoxonase-1 was lower in Type 2 DM patients and being positively correlated with HDL-c and inversely correlated with HbA1c.