Evaluation of Platelets Count and Mean Platelets Volume in Type2 Diabetes patients in Hospitals of Sanaa City - Yemen

Abstract

Background: Type 2 diabetes mellitus is frequently associated with increased platelet activation, contributing to vascular complications. Mean platelet volume and platelet count are accessible hematological indices that may reflect platelet function and disease progression.

Objective: This study aimed to evaluate platelet count and mean platelet volume among Type 2 diabetes mellitus patients and explore their relationship with the duration of diabetes, glycemic control, and body mass index.

Methods: A cross-sectional study was conducted involving 371 patients with Type 2 diabetes mellitus attending three major hospitals in Sana’a from September 2024 to July 2025. Data on demographics, clinical history, and hematological indices were collected and analyzed using SPSS (version 28.0).

Results: The mean platelet count was 295.66 ± 90.24 ×10/L, and the mean platelet volume was 9.83 ±1.47 fL. The platelet count was significantly higher in patients with diabetes duration of 6 years than in those with diabetes duration of <6 years (p = 0.025). Platelet count was positively correlated with fasting blood sugar (p = 0.013), body mass index (p = 0.001), and diabetes duration (p = 0.004). A significant negative correlation was found between the platelet count and MPV (p = 0.001).

Conclusion: Platelet count increases with longer diabetes duration, indicating possible progressive platelet activation. However, mean platelet volume was not a reliable indicator of diabetic progression in this cohort. Platelet count may serve as a cost-effective marker for long-term monitoring in low-resource settings, such as
Yemen.