KCNQ1 Variant rs2237892 Linked with Type 2 Diabetes in Yemeni Individuals

الملخص

Introduction: The pathophysiology of type 2 diabetes mellitus involves both resistance to insulin and insufficient insulin secretion by the pancreatic β-cell. According to earlier genomic studies, T2D is associated with slight changes in single-nucleotide polymorphisms (SNPs) essential for insulin release. The study aimed to investigate the correlation between T2D with a specific genetic variant (SNP) in the KCNQ1 gene, known as rs2237892, among Yemeni people.

  Method: In a case-control study, an allelic discrimination assay and TaqMan Real-Time PCR technology were used to genotype 150 Yemeni adults with diabetes and 150 without it.

  Results: Triglyceride, total cholesterol, and LDL-C levels were significantly higher in the T2D group compared to healthy controls (P < 0.001). After adjusting the age and BMI, neither the dominant nor the additive genetic models showed a statistically significant association with T2D (OR = 0.335, P = 0.153; OR = 1.489, P = 0.15, respectively). However, the recessive genetic model for the KCNQ1 SNP rs2237892 demonstrated a significant association with T2D among Yemeni individuals (OR = 2.69, P = 0.01).

  Conclusion: This study identifies a significant correlation between the recessive model of KCNQ1 rs2237892 polymorphism and T2D susceptibility among Yemeni individuals

  Keywords: KCNQ1; SNP; type 2 diabetes; Yemeni individuals.