Assessment of Rheumatoid Arthritis DiseaseActivity and Association Factors among YemeniPatients
Background: Rheumatoid arthritis is a common autoimmune inflammatory disorder leading to disability and joint deformity. Assessment of rheumatoid arthritis disease activity is a significant step in improving its management.
Aim: To assess the Rheumatoid arthritis disease activity and association factors among Yemeni patients.
Methods: This cross-sectional study included 140 cases of Rheumatoid arthritis at the rheumatology clinic in Sana’a and Ibb cities. Patients were diagnosed according to the American College of Rheumatology and European Alliance of Associations for Rheumatology 2010 and divided into three groups based on the Disease Activity Score-28 joints (low, moderate, and high). Laboratory tests, including CBC, erythrocyte sedimentation rate, rheumatoid factor, and serum anti-cyclic citrullinated peptide levels, were evaluated.
Results: Among 140 RA patients, 115 (82.1%) were female and 25 (17.9%) were male. A total of 86% of patients had moderate to high disease activity (DAS28-ESR ≥3.2) with a mean DAS28-ESR score of 4.95±1.03. A significant correlation of tender and swollen joint counts, erythrocyte sedimentation rate, and anti-cyclic citrullinated peptide with DAS28-ESR was observed (P<0.05), whereas no correlation was observed between the duration of disease and RF with disease activity.
Conclusion: This study indicates that the majority of patients experience moderate to high disease activity. The results revealed that the factors associated with disease activity were the number of tender and swollen joints, ESR, and anti-cyclic citrullinated peptide levels. These findings underscore the critical importance of early diagnosis and improved access to effective treatment options.
المقاييس
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